The ARI Fancy Lightbox appears to do a great job at adding no only lightboxes to images on your site that link to themselves, but also the ability to zoom in and pan around on those images.
WP Lightbox with Zoom
The ARI Fancy Lightbox appears to do a great job at adding no only lightboxes to images on your site that link to themselves, but also the ability to zoom in and pan around on those images.